VAV1 Monoclonal Antibody

SKU: BT-MCA2621

Size:100μL

Background:The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Research_area:Signal Transduction

Target_protein:VAV1

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2E11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:VAV1

Immunogen:Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):98.3kDa

UniProt accession:P15498

Synonyms:VAV

GeneID:7409