USP2 Polyclonal Antibody

SKU: E-AB-10878

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:USP2

Target Synonym:41 kDa ubiquitin specific protease;41 kDa ubiquitin-specific protease;Deubiquitinating enzyme 2;Ubiquitin carboxyl terminal hydrolase 2;Ubiquitin carboxyl-terminal hydrolase 2;ubiquitin specific peptidase 2;Ubiquitin specific processing protease 2;Ubiquitin specific protease 12;Ubiquitin specific protease 9;Ubiquitin specific protease;41kD;Ubiquitin thioesterase 2;Ubiquitin thiolesterase 2;Ubiquitin-specific-processing protease 2;Ubiquitin-specific-processing protease testis;UBP-t;UBP2;UBP41;USP2;USP9

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O75604

Accession:

Background:This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Concentration:0.3 mg/mL

Immunogen:Recombinant protein of human USP2

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: