uPA antibody , Cat. # FNab09267

SKU: FNab09267

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:PLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1(PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder(QPD).

Immunogen:plasminogen activator, urokinase

Synonyms:ATF, PLAU, U plasminogen activator, uPA, URK

Observed MW:54 kDa

Uniprot ID:P00749

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IP, IF

Recommended dilution:WB: 1:500-1:1000; IHC?1:20-1:200?IF: 1?20-1?200; IP: 1?500-1?2000

Gene ID:5328

Research Area:Immunology, Cardiovascular, Signal Transduction