TSPAN12 antibody , Cat. # FNab09055

SKU: FNab09055

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Immunogen:tetraspanin 12

Synonyms:NET 2, NET2, Tetraspan NET 2, tetraspanin 12, TM4SF12, Tspan 12, TSPAN12

Observed MW:28 kDa

Uniprot ID:O95859

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB

Recommended dilution:WB: 1:200-1:2000

Gene ID:23554

Research Area:Cardiovascular, Signal Transduction