TRPV1 Antibody, Biotin conjugated - Cat. #: CSB-PA822774LD01HU

SKU: CSB-PA822774LD01HU

Size :50ug

Clone Number:

Aliases:Capsaicin receptor antibody; DKFZp434K0220 antibody; osm 9 like TRP channel 1 antibody; Osm-9-like TRP channel 1 antibody; OTRPC1 antibody; Transient receptor potential cation channel subfamily V member 1 antibody; TRPV 1 antibody; Trpv1 antibody; TRPV1_HUMAN antibody; Vanilloid receptor 1 antibody; Vanilloid receptor subtype 1 antibody; VR 1 antibody; VR1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8NER1

Immunogen:Recombinant Human Transient receptor potential cation channel subfamily V member 1 protein (1-155AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TRPV1

Research Areas:Neuroscience