TRPM4 Antibody - Cat. #: CSB-PA819465ESR2HU

SKU: CSB-PA819465ESR2HU

Size :50ul

Clone Number:

Aliases:1110030C19Rik antibody; AW047689 antibody; Calcium-activated non-selective cation channel 1 antibody; FLJ20041 antibody; hTRPM4 antibody; Long transient receptor potential channel 4 antibody; LTrpC-4 antibody; LTrpC4 antibody; Melastatin 4 antibody; Melastatin like 2 protein antibody; Melastatin-4 antibody; Melastatin-like 2 antibody; Mls2s antibody; PFHB1B antibody; Transient receptor potential cation channel subfamily M member 4 antibody; Transient receptor potential cation channel, subfamily M, member 4 antibody; Trpm4 antibody; TRPM4_HUMAN antibody; TRPM4B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8TD43

Immunogen:Recombinant Human Transient receptor potential cation channel subfamily M member 4 protein (1-240AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TRPM4

Research Areas:Neuroscience; Cancer; Metabolism; Signal transduction