TOPBP1 Antibody - Cat. #: CSB-PA846078ESR2HU

SKU: CSB-PA846078ESR2HU

Size :50ul

Clone Number:

Aliases:DNA topoisomerase 2 binding protein 1 antibody; DNA topoisomerase 2-binding protein 1 antibody; DNA topoisomerase II binding protein 1 antibody; DNA topoisomerase II binding protein antibody; DNA topoisomerase II-beta-binding protein 1 antibody; DNA topoisomerase II-binding protein 1 antibody; DNA topoisomerase IIbeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; TOPB1_HUMAN antibody; TOPBP 1 antibody; TopBP1 antibody; Topoisomerase (DNA) II binding protein 1 antibody; Topoisomerase II binding protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q92547

Immunogen:Recombinant Human DNA topoisomerase 2-binding protein 1 protein (1253-1522AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TOPBP1

Research Areas:Epigenetics and Nuclear Signaling