TNNI2 Monoclonal Antibody

SKU: BT-MCA4469

Size:100μL

Background:This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

Research_area:Signal transduction

Target_protein:TNNI2

applications:IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2F12A8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:TNNI2

Immunogen:Purified recombinant fragment of human TNNI2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):21kDa

UniProt accession:P48788

Synonyms:DA2B, FSSV, fsTnI, AMCD2B

GeneID:7136