TNFRSF10B Monoclonal Antibody

SKU: BT-MCA4707

Size:100μL

Background:The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Research_area:Signal transduction, Cardiovascular, Cancer

Target_protein:TNFRSF10B

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:2H5B8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:TNFRSF10B

Immunogen:Purified recombinant fragment of human TNFRSF10B (AA: extra 56-210) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):47.9kDa

UniProt accession:O14763

Synonyms:DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5

GeneID:8795