TLK1 Antibody - Cat. #: CSB-PA178566

SKU: CSB-PA178566

Size :100ul

Clone Number:

Aliases:PKU beta antibody; PKU-beta antibody; serine threonine protein kinase antibody; Serine/threonine protein kinase tousled like 1 antibody; Serine/threonine-protein kinase tousled-like 1 antibody; SNARE protein kinase SNAK antibody; Tlk1 antibody; TLK1_HUMAN antibody; Tousled like kinase 1 antibody; Tousled-like kinase 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UKI8

Immunogen:Synthesized peptide derived from internal of Human TLK1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Yamakawa A., Gene 202:193-201(1997).
Sillje H.H.W., EMBO J. 18:5691-5702(1999).
Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TLK1

Research Areas:Epigenetics and Nuclear Signaling;Signal transduction