TERF2IP Antibody - Cat. #: CSB-PA878922DSR2HU

SKU: CSB-PA878922DSR2HU

Size :50ul

Clone Number:

Aliases:Dopamine receptor interacting protein 5 antibody; Dopamine receptor-interacting protein 5 antibody; DRIP 5 antibody; DRIP5 antibody; hRap1 antibody; MGC105533 antibody; RAP 1 antibody; RAP1 homolog antibody; RAP1, yeast, homolog if antibody; RAP1, yeast, homolog of antibody; Repressor/activator protein 1 homolog antibody; TE2IP_HUMAN antibody; Telomeric Repeat Binding Factor 2 Interacting Protein antibody; Telomeric repeat-binding factor 2-interacting protein 1 antibody; TERF2-interacting protein antibody; TERF2-interacting telomeric protein 1 antibody; TERF2IP antibody; TRF2 Interacting Telomeric Protein RAP1 antibody; TRF2 interacting telomeric RAP1 protein antibody; TRF2-interacting telomeric protein 1 antibody; TRF2-interacting telomeric protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NYB0

Immunogen:Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5\\\'-TTAGGG-3\\\' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TERF2IP

Research Areas:Epigenetics and Nuclear Signaling; Tags & Cell Markers