TCL1A Monoclonal Antibody

SKU: BT-MCA3865

Size:100μL

Background:Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).

Research_area:Epigenetics and nuclear signaling, Cancer

Target_protein:TCL1A

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2E3A5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:TCL1A

Immunogen:Purified recombinant fragment of human TCL1A (AA: 10-104) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):13.5kDa

UniProt accession:P56279

Synonyms:TCL1

GeneID:8115