SNX13 rabbit pAb

SKU: ES13032

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human; Mouse

Dilution:WB 1:500-2000

Immunogen:Synthesized peptide derived from human SNX13 AA range: 602-652

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):105kD

Human_gene_id:23161

Human_swiss_prot_no:Q9Y5W8

Subcellular_location:Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .

Other_name:Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)

Background:This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],