SNCB Antibody - Cat. #: CSB-PA923389

SKU: CSB-PA923389

Size :100ul

Clone Number:

Aliases:14 kDa brain-specific protein antibody; Beta-synuclein antibody; Phosphoneuroprotein 14 antibody; PNP14 antibody; Sncb antibody; Synuclein beta antibody; SYUB_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q16143

Immunogen:Synthesized peptide derived from Human Synuclein ? antibody.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 - 3011.
Makoto Hashimoto, J. Biol. Chem., May 2004; 279: 23622 - 23629.
Cristine Alves da Costa, J. Biol. Chem., Sep 2003; 278: 37330 - 37335.
Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 - 7569.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SNCB

Research Areas:Neuroscience