Smad3 (4C9) Mouse mAb

SKU: EM1315

Size: 100μL

Source:Mouse

Applications:WB, IHC

Reactivity:Human, Rat, Mouse

Dilution:WB 1:1,000-2,000 IHC 1:100-200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):52kDa

Human_gene_id:4088

Human_swiss_prot_no:P84022

Subcellular_location:Cytoplasm, Nucleus

Other_name:hMAD3 antibody, HSPC193 antibody, LDS1C antibody, MADH3 antibody, JV15 2 antibody

Background:Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription.