SETD7 Antibody, FITC conjugated - Cat. #: CSB-PA840975LC01HU

SKU: CSB-PA840975LC01HU

Size :50ug

Clone Number:

Aliases:FLJ21193 antibody; H3 K4 HMTase antibody; H3-K4-HMTase SETD7 antibody; H4 lysine 4 specific antibody; Histone H3 K4 methyltransferase antibody; Histone H3 lysine 4 specific methyltransferase antibody; Histone H3-K4 methyltransferase SETD7 antibody; Histone H4 K4 methyltransferase antibody; Histone lysine N methyltransferase antibody; Histone lysine N methyltransferase H3 lysine 4 specific SET7 antibody; Histone-lysine N-methyltransferase SETD7 antibody; KIAA1717 antibody; KMT7 antibody; Lysine methyltransferase antibody; Lysine N-methyltransferase 7 antibody; OTTHUMP00000164543 antibody; OTTHUMP00000220049 antibody; SET 7 antibody; SET 7/9 antibody; SET 9 antibody; SET D7 antibody; SET domain containing (lysine methyltransferase) 7 antibody; SET domain containing protein 7 antibody; SET domain containing protein 8 antibody; SET domain-containing protein 7 antibody; SET7 antibody; SET7/9 antibody; SET9 antibody; Setd7 antibody; SETD7_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WTS6

Immunogen:Recombinant Human Histone-lysine N-methyltransferase SETD7 protein (1-218AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Histone methyltransferase that specifically monomethylates \\\'Lys-4\\\' of histone H3. H3 \\\'Lys-4\\\' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates \\\'Lys-189\\\' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates \\\'Lys-372\\\' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SETD7

Research Areas:Epigenetics and Nuclear Signaling