SDCBP Antibody - Cat. #: CSB-PA020893LA01HU

SKU: CSB-PA020893LA01HU

Size :50ug

Clone Number:

Aliases:MDA-9 antibody; MDA9 antibody; Melanoma differentiation-associated protein 9 antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody; Scaffold protein Pbp1 antibody; SDCB1_HUMAN antibody; SDCBP antibody; ST1 antibody; SYCL antibody; Syndecan binding protein (syntenin) antibody; Syndecan binding protein 1 antibody; Syndecan-binding protein 1 antibody; Syntenin 1 antibody; Syntenin-1 antibody; TACIP18 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O00560

Immunogen:Recombinant Human Syntenin-1 protein (21-228AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background:Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SDCBP

Research Areas:Neuroscience