Scribble (phospho-Ser1220) rabbit pAb

SKU: ES13179

Size: 100μL

Source:Rabbit

Applications:WB;ELISA;IHC

Reactivity:Human;Mouse

Dilution:WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Immunogen:Synthesized phosho peptide around human Scribble (Ser1220)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):179kD

Human_gene_id:23513

Human_swiss_prot_no:Q14160

Subcellular_location:Cell membrane ; Peripheral membrane protein. Cell junction . Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). .

Other_name:Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)

Background:This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011],