S26A5 rabbit pAb

SKU: ES13250

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human; Mouse; Rat

Dilution:IHC-p 1:100-500

Immunogen:Synthesized peptide derived from human S26A5

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):81kD

Human_gene_id:375611

Human_swiss_prot_no:P58743

Subcellular_location:Cell membrane ; Multi-pass membrane protein . Lateral wall of outer hair cells. .

Other_name:Prestin (Solute carrier family 26 member 5)

Background:This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009],