RUNX2 antibody , Cat. # FNab07536

SKU: FNab07536

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE)(By similarity). Inhibits KAT6B-dependent transcriptional activation.

Immunogen:runt-related transcription factor 2

Synonyms:AML3, CBFA1, OSF2, PEBP2A

Observed MW:70 kDa

Uniprot ID:Q13950

Reactivity:Human, Mouse

Tested Application:ELISA, WB

Recommended dilution:WB: 1:200-1:2000

Gene ID:860

Research Area:Stem Cells, cancer, Neuroscience, Developmental biology