RPGF4 Polyclonal Antibody

SKU: BT-AP13915

Size:100μL

Background:The DEP domain is involved in membrane localization independent from regulation by cAMP.,The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.,Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.,Contains 1 DEP domain.,Contains 1 N-terminal Ras-GEF domain.,Contains 1 Ras-GEF domain.,Contains 2 cyclic nucleotide-binding domains.,subunit:Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.,tissue specificity:Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.,

Research_area:Signal transduction

Target_protein:RAPGEF4

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Rap guanine nucleotide exchange factor 4

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q8WZA2; Mouse: Q9EQZ6; Rat: Q9Z1C7

Synonyms:Rap guanine nucleotide exchange factor 4 ;Exchange factor directly activated by cAMP 2;Exchange protein directly activated by cAMP 2;EPAC 2;cAMP-regulated guanine nucleotide exchange factor II

GeneID:Human: 11069