ROCK1 Monoclonal Antibody

SKU: BT-MCA2623

Size:100μL

Background:This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Research_area:Signal Transduction

Target_protein:ROCK1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:1H4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ROCK1

Immunogen:Purified recombinant fragment of human ROCK1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):158kDa

UniProt accession:Q13464

Synonyms:ROCK-I, PRO0435, MGC43611, P160ROCK, MGC131603

GeneID:6093