RIP3 antibody , Cat. # FNab07312

SKU: FNab07312

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Immunogen:receptor-interacting serine-threonine kinase 3

Synonyms:Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3

Observed MW:57 kDa

Uniprot ID:Q9Y572

Reactivity:Human, Mouse

Tested Application:ELISA, IP, WB,IHC

Recommended dilution:WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400

Gene ID:

Research Area:Signal Transduction, Metabolism