RHOB Antibody - Cat. #: CSB-PA916815

SKU: CSB-PA916815

Size :100ul

Clone Number:

Aliases:Aplysia RAS-related homolog 6 antibody; ARH6 antibody; ARHB antibody; H6 antibody; MST081 antibody; MSTP081 antibody; oncogene RHO H6 antibody; ras homolog family member B antibody; ras homolog gene family; member B antibody; Rho cDNA clone 6 antibody; Rho related GTP binding protein RhoB Precursor antibody; Rho-related GTP-binding protein RhoB antibody; Rhob antibody; RHOB_HUMAN antibody; RHOH6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P62745

Immunogen:Synthesized peptide derived from internal of Human RHOB.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Chardin P., Nucleic Acids Res. 16:2717-2717(1988).
Puhl H.L. III, Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RHOB

Research Areas:Signal transduction