Recombinant TBC1D4 Monoclonal Antibody

SKU: AN300720L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:TBC1D4

Target Synonym:KIAA;NIDDM;TBC1D;AS160;NIDDM5;TBC1D4;KIAA0603;Acrg embryonic lethality (mouse) minimal region ortholog;Acrg embryonic lethality minimal region ortholog;Acrg embryonic lethality mouse minimal region ortholog;Akt substrate of 160 kDa;AS 160;BUB2;CDC16;TBC (Tre 2 BUB2 CDC16) domain containing protein;TBC Tre 2 BUB2 CDC16 domain containing protein;TBC1 D4;TBC1 domain family member 4;TBCD4;Tre-2

Research Areas:Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:11A2

UNIProt ID:O60343

Accession:

Background:This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human TBC1D4 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;

Calculated MW:147 kDa

ObservedMW:160 kDa