Recombinant Smad2 Monoclonal Antibody

SKU: AN301013L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Smad2

Target Synonym:MADH;MADR;hMAD;SMAD;hSMAD;JV18;JV18-1;MADH2;MADR2;hMAD-2;hSMAD2;Smad2;Drosophila;homolog of;hSMAD family member 2;JV181;MAD;MAD homolog 2;MAD Related Protein 2;Mad-related protein 2;MGC22139;MGC34440;Mother against DPP homolog 2;Mothers against decapentaplegic;Mothers against decapentaplegic homolog 2;Mothers against DPP homolog 2;OTTHUMP00000163489;Sma and Mad related protein 2;Sma- and Mad-related protein 2 MAD;SMAD 2;SMAD family member 2

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling;Stem Cells;Cancer;Kits;Lysates;Other;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:2B9

UNIProt ID:Q15796

Accession:

Background:The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Smad2 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000;

Calculated MW:58 kDa

ObservedMW:58 kDa