Recombinant SLC25A12 Monoclonal Antibody

SKU: AN301939L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:SLC25A12

Target Synonym:AGC;EIEE;SLC25A;SLC25A12;AGC1;ARALAR;EIEE39;ARALAR1;Araceli hiperlarga;Calcium binding mitochondrial carrier superfamily member;Calcium binding mitochondrial carrier superfamily member Aralar1;Calcium-binding mitochondrial carrier protein Aralar1;CMC1;member 12;Mitochondrial aspartate glutamate carrier 1;solute carrier family 25;Solute carrier family 25 (aspartate/glutamate carrier) member 12;Solute carrier family 25 (mitochondrial carrier Aralar) member 12;Solute carrier family 25 member 12

Research Areas:Neuroscience;Tags & Cell Markers;Signal Transduction;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A655

UNIProt ID:O75746

Accession:

Background:The calcium-binding mitochondrial carrier protein (SLC25A12), also named as ARALAR or AGC1, is an aspartate-glutamate exchange protein responsible for transporting mitochondrial aspartate across the mitochondrial inner membrane in exchange for cytosolic glutamate. SLC25A12 and other proteins of the aspartate-glutamate carrier (AGC) group are required for the transfer of mitochondrial aspartate to the cytosol, a key step in urea synthesis. Research studies using SLC25A12-knockout mice indicate that SLC25A12 plays an important role in proper CNS myelination. Mice lacking SLC25A12 suffer from hypomyelination as a result of a lack of oligodendrocyte maturation caused by decreased brain N-acetylaspartate levels. Mutation of the corresponding SLC25A12 gene can result in global cerebral hypomyelination and severe psychomotor retardation, caused by deficient SLC25A12 activity and limited mitochondrial aspartate efflux.

Concentration:1 mg/mL

Immunogen:Recombinant human SLC25A12 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:2000-1:5000;IHC 1:50-1:100

Calculated MW:75 kDa

ObservedMW:75 kDa