Recombinant Rat VCC-1/CXCL17 protein

SKU: CD00067

Size:2 ug

Background:CXCL17 also named Dendritic Cell and Monocyte Chemokine-like Protein (DMC) and VEGF Co-regulated Chemokine 1 (VCC-1), is a small cytokine belonging to the CXC chemokine family. It is constitutively expressed in the lung and can be detected in trachea, stomach and skeletal muscle. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It may be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues and may play a role in the innate defense against infections. Mature human CXCL17 shares 73 %, 71 % and 64 % amino acid sequence identity with bovine, mouse and rat DMC, respectively.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Rat VEGF Co-regulated Chemokine 1/CXCL17

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by its ability to induce VEGF expression using Mouse endothelial cells is less than 5. μg/ml, corresponding to a specific activity of > 2 IU/mg.

Synonyms:VCC-1/CXCL17, Rat

Endotoxin:Less than 1 EU/μg of rRtVCC-1/CXCL17 as determined by LAL method.

Storage:-20ºC

Sequence:SPNQEVARHH GDQHQAPRRW LWEGGQECDC KDWSLRVSKR KTTAVLEPPR KQCPCDHVKG SEKKNRRQKH HRKSQRPSRT CQQFLKRCQL ASFTLPL

uniprot accession:P4861

Molecular weight:Approximately 11.5 kDa, a single non-glycosylated polypeptide chain containing 97 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH 7.4.