Recombinant Rat C10/CCL6 protein

SKU: CD00140

Size:2 ug

Background:Chemokine (C-C motif) ligand 6 (CCL6), encoded by the gene CCL6, is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. It signals primarily through the CCR1 receptor. CCL6 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. It contains the four highly conserved cysteine residues present in CC chemokines. The completed rat CCL6 sequence is 115 amino acids (a.a.) containing 21 a.a. signal peptide. It has about 78 % identity with mouse homologue (116 a.a.).

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Rat Protein CCL6

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CCR1 transfected Mouse BaF3 cells is in a concentration range of 1-1 ng/ml.

Synonyms:C1/CCL6, Mrp-1, Scay6,Rat

Endotoxin:Less than 1 EU/μg of rRtC10/CCL6 as determined by LAL method.

Storage:-20ºC

Sequence:GLIQDTVKED RPFNPTIIHQ GFQDSSDCCF SYASQIPCSR FIYYFPTSGG CTKPGIIFVT RKRKRVCANP SDQRVQTCIS TLKLGPRSGN SAIA

uniprot accession:Q68FP3

Molecular weight:Approximately 1.4 kDa, a single non-glycosylated polypeptide chain containing 94 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 5 mM NaCl.