Recombinant QKI Monoclonal Antibody

SKU: AN301863L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:QKI

Target Synonym:QKI;Hqk;QK;QK1;QK3;hqkI;HKQ

Research Areas:Neuroscience;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A575

UNIProt ID:Q96PU8

Accession:

Background:QKI is a member of the signal transduction and activator of RNA (STAR) protein family of RNA-binding proteins. Mutations in the mouse Qki locus results in impaired myelin formation resulting in tremors. QKI proteins exist as homodimers, and disruption of the dimerization process is lethal in mice. QKI exists in different isoforms that differ in their C-terminus, resulting in unique subcellular localizations. The nuclear isoform of QKI, QKI-5, is involved in regulation of alternative splicing of MAG mRNA, which encodes for a protein important for myelin sheath formation and maintenance. QKI has also been implicated in schizophrenia and oligodendrocyte differentiation. QKI can function as a tumor suppressor, as it is regulated by p53 to stabilize miRNAs that regulate TGF-β signaling.

Concentration:1 mg/mL

Immunogen:Recombinant human QKI fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:3000;IF 1:50

Calculated MW:38 kDa

ObservedMW:38 kDa