Recombinant PRKACA Monoclonal Antibody

SKU: AN300927L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:PRKACA

Target Synonym:PPNAD;PRKACA;PKACA;PPNAD4;cAMP dependent protein kinase alpha catalytic subunit;cAMP dependent protein kinase beta catalytic subunit;cAMP dependent protein kinase catalytic beta subunit isoform 4ab;cAMP dependent protein kinase catalytic subunit alpha;cAMP dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha;isoform 1;KAPCA;PKA C alpha;PKA C beta;PKA C-alpha;PKACB;PRKACAA;PRKACB;Protein kinase A catalytic subunit;Protein kinase A catalytic subunit alpha;Protein kinase A catalytic subunit beta;Protein kinase cAMP dependent catalytic alpha;Protein kinase cAMP dependent catalytic beta;protein kinase cAMP-activated catalytic subunit alpha;PKA

Research Areas:Signal Transduction;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:8A3

UNIProt ID:P17612

Accession:

Background:This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human PRKACA protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000

Calculated MW:40 kDa

ObservedMW:40 kDa