Recombinant Phospho-YAP1 (Ser127) Monoclonal Antibody

SKU: AN302080L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies;Acetyl/Phospho/Methyl Antibodies

Abbreviation:Phospho-YAP1 (Ser127)

Target Synonym:COB;COB1;YAP;YAP2;YAP65;YKI;YAP1;65 kDa Yes associated protein;65 kDa Yes-associated protein;Basic protease inhibitor;BPTI;Pancreatic Trypsin Inhibitor;Trasylol;YAp 1;YAP 65;Yes associated protein 1;Yes associated protein 1 65kDa;Yes associated protein 2;yes associated protein beta;yes -associated protein delta;Yorkie homolog

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC;IF;FCM

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A804

UNIProt ID:P46937

Accession:

Background:Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

Concentration:1 mg/mL

Immunogen:phosphorylated human YAP1 (Ser1270) peptide

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:100-1:200;IF 1:50;FCM 1:50-1:100

Calculated MW:54 kDa

ObservedMW:70-100 kDa