Recombinant Phospho-HER3/ErbB3 (Tyr1289) Monoclonal Antibody

SKU: AN300020L

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:ERBB3

Target Synonym:HER;LCCS;Proto-oncogene-like protein c-ErbB;Tyrosine kinase-type cell surface receptor HER;MDA-BF;p180-ErbB;p45-sErbB;p85-sErbB;ERBB3;ErbB-3;HER3;LCCS2;MDA-BF-1;c-erbB-3;c-erbB3;erbB3-S;p180-ErbB3;p45-sErbB3;p85-sErbB3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3;EEBB3

Research Areas:Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:5A5

UNIProt ID:P21860

Accession:

Background:This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Concentration:1 mg/mL

Immunogen:A synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human Phospho-HER3/ErbB3

Buffer:10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Purification method:Protein A

Dilution:WB 1:2000-1:20000;

Calculated MW:148 kDa

ObservedMW:250 kDa