Recombinant Neutrophil Elastase Monoclonal Antibody

SKU: AN301873L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Neutrophil Elastase

Target Synonym:SCN;ELA;Elastase;ELANE;ELA2;GE;HLE;HNE;NE;PMN-E;SCN1;Elastase-2;Medullasin;Neutrophil elastase;Bone marrow serine protease;Human leukocyte elastase;PMN elastase;Elastase 2;Elastase 2 neutrophil;Elastase neutrophil expressed;ELNE;Granulocyte derived elastase;Leukocyte elastase;Neutrophil expressed;PMN E;Polymorphonuclear elastase

Research Areas:Immunology;Microbiology;Signal Transduction;Cancer;Kits;Lysates;Other

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A585

UNIProt ID:P08246

Accession:

Background:Neutrophil Elastase is hematopoietic serine protease that belongs to the chymotrypsin superfamily and plays a critical role in the innate immune function of mature neutrophils and monocytes. Neutrophil elastase is actively synthesized as an inactive zymogen in myelocytic precursor cells of the bone marrow, which then undergoes activation by limited proteolysis and sorting to primary (azurophil) storage granules of mature neutrophil granulocytes for regulated release. Research studies have shown that neutrophils play a significant role in mediating the inflammatory response through the release of neutrophil elastase, which activates pro-inflammatory cytokines and degrades components of the extracellular matrix and Gram-negative bacteria. Mutations in the gene encoding neutrophil elastase, ELA2, have been implicated in hematological diseases such as cyclic and severe congenital neutropenia, which is characterized by defects in promyelocyte maturation.

Concentration:1 mg/mL

Immunogen:Recombinant human Neutrophil Elastase fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:5000

Calculated MW:29 kDa

ObservedMW:29 kDa