Recombinant Mouse TRAIL R2/TNFRSF10B Protein (AVI & His Tag)

SKU: PKSM041369

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: TRAIL R2;TNFRSF10B

Target Synonym: CD262;DR5;Death Receptor 5;KILLER;TNF-Related Apoptosis-Inducing Ligand Receptor 2;TNFRSF10B;TRAIL Receptor 2;TRAIL-R2;TRAILR2;TRICK2;Tumor Necrosis Factor Receptor Superfamily Member 10B;ZTNFR9

Research Areas:

Conjugation: Biotinylated

Target Species: Mouse

Expression Host: HEK293 Cells

Application:

Fusion tag: C-Avi-His

UNIProt ID: Q9QZM4

Accession: Q9QZM4

Background: Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.

Concentration:

Activity: Not validated for activity

Sequence: Asn53-Ser177

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 16.4 kDa

ObservedMW: 20-40 kDa