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GeneBio Systems

Recombinant MEK2 Monoclonal Antibody

Recombinant MEK2 Monoclonal Antibody

AN301599L

€349,95 EUR
€349,95 EUR
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Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:MEK2

Target Synonym:MEK;MKK;CFC;MAPKK;PRKMK;MAP2K;CFC4;MAPKK2;MEK2;MKK2;PRKMK2;MAP2K2;Cardiofaciocutaneous syndrome;CFC syndrome;Dual specificity mitogen activated protein kinase kinase 2;Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;FLJ26075;MAP kinase kinase 2;MAPK / ERK kinase 2;MAPK/ERK kinase 2;MAPKK 2;MEK 2;Microtubule associated protein kinase kinase 2;Mitogen activated protein kinase kinase 2;Mitogen activated protein kinase kinase 2 p45;MKK 2;MP2K2;OTTHUMP00000165826;OTTHUMP00000165827;PRKMK 2

Research Areas:Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A302

UNIProt ID:P36507

Accession:

Background:The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.

Concentration:1 mg/mL

Immunogen:Recombinant human MEK2 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:100-1:1000

Calculated MW:44 kDa

ObservedMW:44 kDa

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