Recombinant Human TNFRSF1B/CD120b Protein (aa 288-461, His Tag)

SKU: PKSH033161

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: TNFRSF1B;CD120b

Target Synonym: TNF-R2;TNF-RII;TNFR-II;Tumor necrosis factor receptor 2;Tumor necrosis factor receptor superfamily member 1B;Tumor necrosis factor receptor type II;p75;p80 TNF-alpha receptor

Research Areas: Signal Transduction;Cell biology;Cardiovascular;Neuroscience;Cancer;immunology;

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: P20333

Accession: P20333

Background: Tumor necrosis factor receptor superfamily member 1B(TNFRSF1B) is expressed by the gene TNFRSF1B. The soluble form is produced from the membrane form by proteolytic processing. It can bind to TRAF2; and interacts with BMX. It can act as the receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha.

Concentration:

Activity: Not validated for activity

Sequence: Lys288-Ser461

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 19.0 kDa

ObservedMW: 33-41 kDa