Recombinant Human TARC/CCL17 protein

SKU: CD00847

Size:5 ug

Background:Human CCL17 also known as thymus and activation-related chemokine (TARC) is encoded by the CCL17 gene located on the chromosome 16 in humans. It is expressed by thymus cells constitutively and phytohemagglutinin-stimulated peripheral blood mononuclear cells transiently. CCL17 signals through the chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes. It plays an important role in skin diseases such as atopic dermatitis, bullous pemphigoid and mycosis fungoides. CCL17 has approximately 24 – 29 % amino acid sequence identity with RANTES, MIP-1α, MIP-1β, MCP-1, MCP-2, MCP-3 and I-309.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Thymus and Activation Regulated Chemokine/CCL17

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.-1 ng/ml.

Synonyms:TARC,CCL17,A-152E5.3, ABCD-2, SCYA17, Human

Endotoxin:Less than 1 EU/μg of rHuTARC/CCL17 as determined by LAL method.

Storage:-20ºC

Sequence:ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S

uniprot accession:Q92583

Molecular weight:Approximately 8.1 kDa, a single non-glycosylated polypeptide chain containing 71 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2mM PB, pH 7.4, 15mM NaCl.