Recombinant Human SPEG/APEG-1 Protein (His Tag)

SKU: PKSH030334

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation:

Target Synonym: APEG-1;APEG1;BPEG;CNM5;SPEGalpha;SPEGbeta

Research Areas: Cardiovascular

Conjugation:

Target Species: Human

Expression Host: E.coli

Application:

Fusion tag: C-His

UNIProt ID: Q15772

Accession: Q15772-4

Background: Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains twofibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform1of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform3of SPEG is predominantly expressed in the aorta. Isoform3of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform3of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform3of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Glu 113

Purity: > 85 % as determined by reducing SDS-PAGE.

Formulation: Supplied as sterile solution of PBS, pH 7.4

Reconstitution: Not Applicable

Endotoxin: Please contact us for more information.

Calculated MW: 14 kDa

ObservedMW: 19 kDa