Recombinant Human PTH1-34 protein

SKU: CD01033

Size:20 ug

Background:Parathyroid hormone (PTH) is a single polypeptide of 84 amino acids. It is a critical hormone in the regulation of Ca2+ homeostasis, secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. The amino terminal (1-34) fragment of parathyroid hormone, called PTH (1-34) reproduces all the activity of the full length mature hormone and has been used therapeutically for treatment of osteoporosis.

Research_area:Others

Purity:> 97% by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Parathyroid Hormone 1-34

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by its ability to induce cAMP accumulation in Mouse MC3T3E1 cells is less than 5 ng/ml, corresponding to a specific activity of > 2. × 14 IU/mg.

Synonyms:PTH，FIH11, Human

Endotoxin:Less than 1EU/μg of rHuPTH1-34 as determined by LAL method.

Storage:-20ºC

Sequence:SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNF

uniprot accession:P127

Molecular weight:Approximately 4.1 kDa, a single non-glycosylated polypeptide chain containing 34 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7..