Recombinant Human MIP-3 Alpha/CCL20 protein

SKU: CD01280

Size:5 ug

Background:CCL20, also named LARC (Liver and Activation-regulated Chemokine), is encoded by CCL20 located on chromosome 2 in humans. The expression can be induced by LPS and some inflammatory cytokines, and it is at a high level in lymph nodes, PBL, fatal liver, fatal lung, appendix and so on. CCL20 has functions of chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors. CCL20 elicits it effects by binding with CCR6 receptor.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Macrophage Inflammatory Protein-3 alpha/CCL20

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1-5 ng/ml.

Synonyms:MIP-3α/CCL2,CK,b4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA2, ST38 Human

Endotoxin:Less than 1 EU/μg of rHuMIP-3α/CCL20 as determined by LAL method.

Storage:-20ºC

Sequence:ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM

uniprot accession:P78556

Molecular weight:Approximately 8. kDa, a single non-glycosylated polypeptide chain containing 7 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 1 mM NaCl.