Recombinant Human KIM-1(C-6His)

SKU: PKSH033813

Size: 1mg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: KIM-1

Target Synonym: HAVCR;HAVCR-1;HAVCR1;Hepatitis A virus cellular receptor 1;KIM-1;KIM1;TIM;TIM-1;TIM1;TIMD-1;TIMD1

Research Areas:

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: F1CME6

Accession: F1CME6

Background: Kidney injury molecule-1 (KIM-1) (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. Therefore, KIM-1 is a suitable renal biomarker capable of early detection and progressive monitoring of acute kidney injury beyond traditional injury markers such as serum creatinine (SCr) and blood urea nitrogen (BUN) which lack specificity and sensitivity. KIM-1 has also been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.

Concentration:

Activity: Not validated for activity

Sequence: Ser21-Gly290

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μM filtered solution of PBS,pH7.4,5% Trehalose

Reconstitution: Not Applicable

Endotoxin: Please contact us for more information.

Calculated MW: 29.8 kDa

ObservedMW: 80-120 kDa