Recombinant Human IL1RL1/ST2 Protein

SKU: PKSH031873

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: IL1RL1/ST2

Target Synonym: FIT;DER;IL1RL;IL-1 R;IL1RL1;DER4;FIT-1;IL33R;ST2;ST2L;ST2V;T1;IL-1 R4;DER-4;FIT 1;Growth stimulation expressed;Growth stimulation expressed gene 2;homolog of mouse growth stimulation-expressed;IL-1R4;ILRL1;Interleukin 1 receptor like 1;interleukin 1 receptor related protein;Interleukin-1 receptor-like 1;Protein ST2;T1 protein

Research Areas: Cardiovascular;immunology

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: None

UNIProt ID: Q01638

Accession: NP_003847.2

Background: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Phe 328

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 35.6 kDa

ObservedMW: 55-60 kDa