Recombinant Human I-TAC/CXCL11 protein

SKU: CD01439

Size:5 ug

Background:CXCL11 also known as I-TAC is belonging to the CXC chemokine family and shares 36 % and 37 % amino acid sequence homology with IP-10 and MIG, respectively. It is highly expressed in peripheral blood leukocytes, pancreas and liver. Expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3, which with a higher affinity than do the other chemokines for this receptor, CXCL9 and CXCL10. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human I-TAC/CXCL11

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human IL-2 activated human T-lymphocytes is in a concentration range of .1-1 ng/ml.

Synonyms:I-TAC/CXCL11, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1,Human

Endotoxin:Less than 1 EU/μg of rHuI-TAC/CXCL11 as determined by LAL method.

Storage:-20ºC

Sequence:FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF

uniprot accession:O14625

Molecular weight:Approximately 8.3 kDa, a single non-glycosylated polypeptide chain containing 73 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 1 mM NaCl.