Recombinant Human ESM‑1 Protein(His Tag)

SKU: PDMH100352

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:ESM‑1

Target Synonym:Endothelial cell-specific molecule;Endothelial cell specific molecule;IGFBP-rp;ESM;endocan;ESM1;Endothelial cell specific molecule 1;ESM 1;ESM 1 secretory protein;ESM1 secretory protein;IGFBP-rp6;ESM-1;Endothelial cell-specific molecule 1;endocan;Endothelial cell-specific molecule 1;Endothelial cell-specific molecule 1

Research Areas:Cell Biology;Cardiovascular;Cancer

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:Q9NQ30

Accession:Q9NQ30

Background:ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF or FGF-2. In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against ESM1.

Concentration:

Activity:Not validated for activity

Sequence:Trp20-Arg184

Purity:> 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method

Calculated MW:18.0 kDa

ObservedMW:23-27 kDa