Recombinant Human CXCL7/NAP-2 Protein(Trx Tag)

SKU: PDEH100601

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Cytokines

Abbreviation:CXCL7/NAP-2

Target Synonym:B-TG;CTAP;CXCL;SCYB;C-X-C Motif Chemokine;MDGFSmall-Inducible Cytokine B;LA-PF;NAP;PPBP;B-TG1;Beta-TG;CTAP-III;CTAP3;CTAPIII;CXCL7;LA-PF4;LDGF;MDGF;NAP-2;PBP;SCYB7;TC1;TC2;TGB;TGB1;THBGB;THBGB1;C-X-C Motif Chemokine 7;Leukocyte-Derived Growth Factor;Macrophage-Derived Growth Factor;MDGFSmall-Inducible Cytokine B7;NAP2;Platelet Basic Protein;βTG;B TG1;Beta TG;Beta thromboglobulin;beta-1;Chemokine (C X C motif) ligand 7;Connective tissue activating peptide III;CTAP 3;CTAP III;CTAP-III(1-81);CXC chemokine ligand 7;CXCL 7;LA PF 4;Leukocyte derived growth factor;Low-affinity platelet factor IV;NAP 2;NAP-2(1-63);NAP-2(1-66);NAP-2(73);NAP-2(74);Neutrophil activating peptide 2;Neutrophil-activating peptide 2(1-63);Pro platelet basic protein;Pro platelet basic protein (chemokine (C-X-C motif) ligand 7);Pro-Platelet basic protein;Small inducible cytokine subfamily B member 7;Small-inducible cytokine B7;Thrombocidin 1;Thrombocidin 2;Thromboglobulin;βTG;PBP;CXCL7;NAP2;β-thromboglobulin

Research Areas:Immunology;Cardiovascular;Signal Transduction

Conjugation:

Target Species:Human

Expression Host:E.coli

Application:

Fusion tag:N-Trx

UNIProt ID:P02775

Accession:P02775

Background:Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

Concentration:

Activity:Not validated for activity

Sequence:Ala59-Asp128

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method.

Calculated MW:27.6 kDa

ObservedMW:30 kDa