Recombinant Human CD44 Protein (Fc Tag)

SKU: PKSH032219

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: CD44

Target Synonym: CDW44;CSPG8;ECMR-III;Epican;Extracellular Matrix Receptor III;GP90 Lymphocyte Homing/Adhesion Receptor;HCELL;HUTCH-I;Heparan Sulfate Proteoglycan;Hermes Antigen;Hyaluronate Receptor;IN;LHR;MC56;MDU2;MDU3;MIC4;Pgp1;Phagocytic Glycoprotein

Research Areas: Cancer;immunology;Stem cells

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-Fc

UNIProt ID: P16070

Accession: P16070

Background: CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands; such as osteopontin; collagens; and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore; an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium; stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.

Concentration:

Activity: Not validated for activity

Sequence: Gln21-Pro220

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 49.2 kDa

ObservedMW: 75-95 kDa