Recombinant Human Betacellulin protein

SKU: CD02256

Size:5 ug

Background:Betacellulin (BTC) is a member of the EGF family of cytokines that also includes EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. It is expressed in most tissues including kidney, uterus, liver and pancreas. BTC also presents in body fluids, including serum, milk, and colostrum. At the amino acid sequence level, human mature BTC protein exhibits 80 % identity with mouse BTC protein. The protein binds to EGFR, ERBB4 and other EGF receptor family members and acts as a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Research_area:Immunology

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Betacellulin

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by a cell proliferation assay using Mouse Balb/c 3T3 cells is less than .5 ng/ml, corresponding to a specific activity of > 2. × 17 IU/mg.

Synonyms:Betacellulin, BTC,Human

Endotoxin:Less than 1 EU/μg of rHuBTC as determined by LAL method.

Storage:-20ºC

Sequence:DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

uniprot accession:Q86UF6;Q86UF5

Molecular weight:Recombinant human Betacellulin is a 9. kDa monomeric protein, containing 8 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.