Recombinant Human BCMA protein

SKU: CD02272

Size:5 ug

Background:B-Cell Maturation Antigen (BCMA), encoded by the TNFRSF17 gene in humans. It is a member of the TNF receptor superfamily and a type III membrane protein containing one extracellular cysteine rich domain. It is expressed on mature B-cells and other B-cell lines. BCMA can binds to TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, and has functions that promotes B-cell survival, plays a role in the regulation of humoral immunity, and activates NF-kappa-B and JNK BCMA.

Research_area:Immunology

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human B-Cell Maturation Antigen

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated Mouse B cells is no less than 4 ng/ml, corresponding to a specific activity of > 2.5 × 14 IU/mg in the presence of 1 ng/ml human APRIL.

Synonyms:TNFRSF17,BCM, BCMA, CD269, TNFRSF13A, Human

Endotoxin:Less than 1 EU/μg of rHuBCMA as determined by LAL method.

Storage:-20ºC

Sequence:AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA

uniprot accession:Q2223

Molecular weight:Approximately 5.4 kDa, a single non-glycosylated polypeptide chain containing 5 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 3 % acetonitrile, .1 % TFA.