Recombinant Human 4-1BB Receptor protein

SKU: CD02406

Size:5 ug

Background:4-1BB receptor, also named TNFRSF9 is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB receptor binds to 4-1BBL, and they co-stimulate activity for activated T cells. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. Crosslinking of 4-1BB Receptor enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human 4-1BB Receptor

Biological activity:Fully biologically active when compared to standard. The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 9 % of inibition was seen using a concentration of 1 μg for both 4-1BB Ligand and 4-1BB Receptor.

Synonyms:4-1BB Receptor, 4-1BB, CD137, CDw137, ILA,TNFRSF9 ,Human

Endotoxin:Less than 1 EU/μg of rHu4-1BB Receptor as determined by LAL method.

Storage:-20ºC

Sequence:ERTRSLQDPC SNCPAGTFCD NNRNQICSPC PPNSFSSAGG QRTCDICRQC KGVFRTRKEC SSTSNAECDC TPGFHCLGAG CSMCEQDCKQ GQELTKKGCK DCCFGTFNDQ KRGICRPWTN CSLDGKSVLV NGTKERDVVC GPSPADLSPG ASSVTPPAPA REPGHS

uniprot accession:Q711

Molecular weight:Approximately 17.7 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 1 mM PB, pH 8., 15 mM NaCl.